book: Hemopexin: a unique genetic polymorphism in populations of African ancestry.: An article...

book: Hemopexin: a unique genetic polymorphism in populations of African ancestry.: An article from: Human Biology | M. Ilyas Kamboh, Clareann H. Bunker, ...

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Hemopexin: a uniqu...

	Hemopexin: a unique genetic polymorphism in populations of African ancestry.: An article from: Human Biology M. Ilyas Kamboh, Clareann H. Bunker, ... Wayne State University Press, 1993 - 7 pages
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This digital document is an article from Human Biology, published by Wayne State University Press on August 1, 1993. The length of the article is 1892 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: Using isoelectric focusing and immunoblotting techniques, we have screened 937 plasma or serum samples from Nigerian blacks (N = 380), Papua New Guineans (N = 110), Aleuts (N = 62), Mayans (N = 139), Dogrib Indians (N = 45), and Eskimos from Kodiak and St. Lawrence islands (N = 201) for the hemopexin (HPX) polymorphism. We compared these data with our previously published data for US whites (N = 267) and US blacks (N = 194). Except for Nigerian blacks and US blacks, HPX was found to be monomorphic for the common HPX*1 allele in all populations tested. In addition to the commonly occurring HPX*1 allele, two other less common alleles, HPX*2 and HPX*3, were observed with respective frequencies of 1.8% and 4.6% in US blacks and 1.7% and 9.0% in Nigerian blacks. These data strongly suggest that the HPX*2 and HPX*3 alleles are unique alleles restricted to the black gene pool and are of potential significance in microevolutionary studies and in defining African admixture in hybrid populations. In addition to their importance in anthropogenetic studies, these unique HPX mutations also have potential biological significance in hemolytic disorders.

Citation Details
Title: Hemopexin: a unique genetic polymorphism in populations of African ancestry.
Author: M. Ilyas Kamboh
Publication: Human Biology (Refereed)
Date: August 1, 1993
Publisher: Wayne State University Press
Volume: v65 Issue: n4 Page: p655(6)

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polymorphism